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The relationship between coding sequences and function in some heme binding proteins

P Argos, M G Rossmann

    Journal of Molecular Evolution
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Globin genes have three exons, with the middle one crucial for heme binding. This structure

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Genetics

    Background:

    • Globin genes possess three exons, with the central exon encoding a four-helical structure vital for heme binding.
    • This globin peptide chain structure is structurally similar to cytochrome c and cytochrome b5.

    Purpose of the Study:

    • To infer the exon-intron structure of cytochrome c and cytochrome b5 genes based on structural similarities with globin genes.

    Main Methods:

    • Comparative analysis of protein structures.
    • Inference of gene structure based on conserved functional domains.

    Main Results:

    • The cytochrome c gene is predicted to have a single coding sequence.
    • The cytochrome b5 gene is predicted to have three exons, similar to the globin gene.

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    Conclusions:

    • Gene structure can be inferred from conserved protein supersecondary structures.
    • Evolutionary relationships between heme-binding proteins may be reflected in their gene organization.