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Nitrofurantoin induced erythema nodosum
Journal of the National Medical Association
|January 1, 1981
Summary
Nitrofurantoin can cause erythema nodosum (EN), a skin condition with serum sickness-like symptoms and characteristic lesions. This case report highlights the drug
Area of Science:
- Pharmacology
- Dermatology
- Rheumatology
Background:
- Erythema nodosum (EN) is a panniculitis characterized by tender subcutaneous nodules.
- Drug-induced EN is a recognized phenomenon, but specific causative agents require clear documentation.
- Mitral valve prolapse is a common cardiac condition with varied clinical presentations.
Observation:
- A patient with mitral valve prolapse developed serum sickness-like symptoms.
- The patient presented with both typical and atypical skin lesions of erythema nodosum.
- Pseudo-splinter hemorrhages were observed, adding to the diagnostic complexity.
Findings:
- The case report definitively links nitrofurantoin use to the development of erythema nodosum.
- The clinical presentation included a constellation of symptoms consistent with serum sickness-like reaction.
- The presence of pseudo-splinter hemorrhages is an unusual finding in drug-induced EN.
Implications:
- This report expands the known adverse effects of nitrofurantoin.
- It underscores the importance of considering drug-induced causes in patients presenting with erythema nodosum.
- Clinicians should be vigilant for nitrofurantoin-induced EN, especially in patients with cardiac conditions like mitral valve prolapse.