Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Arsenic compounds and cancer

O Axelson

    Journal of Toxicology and Environmental Health
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Arsenic exposure is linked to lung, skin, and liver cancers in humans. Experimental studies show arsenic may inhibit DNA repair, potentially explaining conflicting cancer findings and cardiovascular risks.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    On the misinterpretation of epidemiological evidence.

    New solutions : a journal of environmental and occupational health policy : NS·2012
    Same author

    Colon-cancer and dietary habits - a case-control study.

    International journal of oncology·2011
    Same author

    Case-control study on colon cancer regarding previous diseases and drug intake.

    International journal of oncology·2011
    Same author

    A case-referent study on acute myeloid leukemia, background radiation and exposure to solvents and other agents.

    Scandinavian journal of work, environment & health·2010
    Same author

    The risk for multiple sclerosis in female nurse anaesthetists: a register based study.

    Occupational and environmental medicine·2006
    Same author

    Occupations and exposures in the work environment as determinants for rheumatoid arthritis.

    Occupational and environmental medicine·2004
    Same journal

    Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up.

    Journal of toxicology and environmental health·1998
    Same journal

    Alterations of male Wistar rat jejunum induced by Dodine (n-dodecylguanidine acetate).

    Journal of toxicology and environmental health·1997
    Same journal

    Cadmium toxicity and distribution in metallothionein-I and -II deficient transgenic mice.

    Journal of toxicology and environmental health·1997
    Same journal

    Comparison of the binding potential of various diisocyanates on DNA in vitro.

    Journal of toxicology and environmental health·1997
    Same journal

    Investigation of the potential impact of benchmark dose and pharmacokinetic modeling in noncancer risk assessment.

    Journal of toxicology and environmental health·1997
    Same journal

    Effect of cypermethrin on isolated male and female rat hepatocytes.

    Journal of toxicology and environmental health·1997
    See all related articles

    Area of Science:

    • Environmental Health
    • Toxicology
    • Carcinogenesis

    Background:

    • Epidemiological studies link arsenic exposure to various cancers, including lung, skin, and liver.
    • Arsenic exposure is associated with specific occupations (copper smelters, pesticide workers) and medical treatments (psoriasis).
    • Animal studies have largely failed to reproduce arsenic-induced carcinogenicity observed in humans.

    Purpose of the Study:

    • To explore the mechanisms behind arsenic's carcinogenicity.
    • To reconcile conflicting findings between human epidemiological data and animal experimental data.
    • To investigate the potential role of DNA repair inhibition in arsenic's effects.

    Main Methods:

    • Review of epidemiological data on arsenic exposure and cancer incidence.

    Related Experiment Videos

  • Analysis of experimental animal studies investigating arsenic carcinogenicity.
  • Examination of in vitro and in vivo evidence for arsenic's effect on DNA repair pathways.

    • Main Results:

    • Human studies show clear associations between arsenic exposure and lung, skin, and liver cancers.
    • Animal models have demonstrated limited success in replicating arsenic's carcinogenic effects.
    • Experimental evidence suggests arsenic interferes with DNA repair mechanisms.

    Conclusions:

    • Arsenic's inhibition of DNA repair may explain discrepancies in carcinogenicity findings.
    • Understanding these mechanisms is crucial for assessing arsenic-related health risks.
    • Further research is needed to fully elucidate arsenic's impact on human health, including cardiovascular effects.