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Chlorinated hydrocarbons and cancer: epidemiologic aspects
Journal of Toxicology and Environmental Health
|September 1, 1980
Summary
Epidemiologic data on halogenated hydrocarbons and cancer is reviewed. While many chlorinated compounds show mutagenic or carcinogenic potential in lab tests, few have been linked to human cancer due to limited research.
Area of Science:
- Environmental Health
- Toxicology
- Epidemiology
Background:
- Halogenated hydrocarbons are widely used as pesticides and industrial solvents.
- Concerns exist regarding their potential health effects, particularly carcinogenicity.
Purpose of the Study:
- To review available epidemiologic information on the link between halogenated hydrocarbons and cancer.
- To assess the current evidence for human carcinogenicity.
Main Methods:
- Literature review of existing epidemiologic studies.
- Analysis of data from bacterial mutagenicity tests and animal experiments.
Main Results:
- Many chlorinated hydrocarbons demonstrate mutagenic or carcinogenic properties in experimental systems.
- Limited human studies have been conducted, associating few substances with human cancer.
Conclusions:
- Experimental evidence suggests carcinogenic potential for numerous halogenated hydrocarbons.
- Further epidemiologic research is needed to establish definitive links to human cancer.