Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Somatic mutation theory

M Sorsa

    Journal of Toxicology and Environmental Health
    |September 1, 1980
    PubMed
    Summary

    Genetic lesions initiate cancer and can cause other health issues. DNA damage in somatic cells leads to tumors, neurological decline, and aging. Fetal exposure to mutagens causes birth defects and childhood cancers.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Assessment of occupational exposure to PAHs in an Estonian coke oven plant- correlation of total external exposure to internal dose measured as 1-hydroxypyrene concentration.

    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2013
    Same author

    Polynuclear aromatic compounds and genotoxicity in particulate and vapor phases of ambient air: effect of traffic, season, and meteorological conditions.

    Environmental science & technology·2011
    Same author

    Examination of ras oncoproteins in human plasma from healthy controls and workers exposed to petroleum emissions, including benzene-related compounds.

    Mutation research·1999
    Same author

    Low response in white blood cell DNA adducts among workers in a highly polluted cokery environment.

    Journal of occupational and environmental medicine·1998
    Same author

    Ethical issues in genetic screening and genetic monitoring of employees.

    Annals of the New York Academy of Sciences·1998
    Same author

    Examination of ras (P21) proteins in plasma from workers exposed to benzene emissions from petrochemical plants and healthy controls.

    Mutation research·1998

    Area of Science:

    • Oncology
    • Genetics
    • Cell Biology

    Background:

    • Genetic lesions are implicated in the initiation of carcinogenesis.
    • Alterations in hereditary material of somatic cells have diverse consequences.
    • Transplacental mutagens can affect fetal development.

    Purpose of the Study:

    • To review evidence supporting the role of genetic lesions in cancer.
    • To discuss other manifestations of DNA damage in somatic cells.
    • To explore the impact of fetal mutagen exposure on development.

    Main Methods:

    • Literature review of genetic lesions and carcinogenesis.
    • Discussion of DNA damage effects on somatic cells.
    • Analysis of transplacental mutagen effects on fetal development.

    Main Results:

    • Genetic lesions are initiating events in multistep carcinogenesis.
    • DNA damage can lead to benign tumors, atherosclerosis, neurological deterioration, and senescence.
    • Fetal exposure to mutagens causes somatic mosaicism, leading to congenital malformations, spontaneous abortions, and childhood cancers.

    Conclusions:

    • Genetic alterations are fundamental to cancer development.
    • Somatic cell DNA damage has wide-ranging health implications.
    • Prenatal exposure to mutagens poses significant risks to fetal development and long-term health.

    Related Experiment Videos