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Experimental infections by Brucella suis type 4 in Alaskan rodents
Journal of Wildlife Diseases
|October 1, 1980
Summary
This study investigated rodent and lagomorph susceptibility to Brucella suis type 4. Varying lemmings showed extreme susceptibility, with even minimal exposure proving fatal.
Area of Science:
- Veterinary Microbiology
- Infectious Diseases
- Zoonotic Pathogens
Background:
- Brucella suis type 4 is a significant pathogen.
- Understanding host susceptibility is crucial for disease control.
Purpose of the Study:
- To experimentally determine the susceptibility of various rodent and lagomorph species to Brucella suis type 4.
- To identify potential reservoir species for this pathogen.
Main Methods:
- Experimental inoculation of nine rodent species and one lagomorph species with Brucella suis type 4.
- Intraperitoneal inoculation route used to administer the bacteria.
- Observation and assessment of pathological responses and mortality.
Main Results:
- All tested species were readily infected with Brucella suis type 4.
- Most species exhibited mild pathological responses.
- Both species of varying lemmings (Dicrostonyx spp.) demonstrated extreme susceptibility, succumbing to infections initiated by as few as two colony-forming units (cfu).
Conclusions:
- Rodents and lagomorphs can be susceptible to Brucella suis type 4.
- Varying lemmings are highly susceptible and may serve as significant reservoirs for Brucella suis type 4.
- Further research into transmission dynamics in these species is warranted.