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Updated: Aug 10, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Summary
Malignant melanoma of the upper extremities had a 63% 10-year survival rate. Early melanoma types showed excellent survival, while advanced or amelanotic melanomas had poorer prognoses, highlighting the need for continued research.
Area of Science:
- Oncology
- Dermatology
- Surgical Oncology
Background:
- Malignant melanoma of the upper extremities represents a significant portion of melanoma cases.
- Understanding long-term survival rates is crucial for patient management and treatment strategies.
Purpose of the Study:
- To analyze the 10-year survival rates of patients with malignant melanoma of the upper extremities.
- To investigate prognostic factors influencing survival, including melanoma type, Clark's level, and surgical intervention.
Main Methods:
- Retrospective analysis of 487 patients treated for malignant melanoma of the upper extremities between 1939 and 1967.
- Calculation of 10-year survival rates based on determinate cases.
- Comparison of survival rates across different melanoma subtypes, Clark's levels, and surgical approaches (elective axillary dissection).
Main Results:
- Overall 10-year survival for 342 determinate patients was 63%.
- Superficial spreading and juvenile melanomas had a 100% 10-year survival, while amelanotic melanoma had a poorer prognosis (20% survival).
- Elective axillary dissection in clinical Stage I patients showed a slightly higher 10-year survival (65%) compared to those without (56%).
Conclusions:
- Malignant melanoma of the upper extremities has a considerable 10-year survival rate, but prognosis varies significantly by subtype.
- Early-stage and superficial melanomas have favorable outcomes, emphasizing the importance of early detection.
- The role of elective axillary dissection warrants further investigation, though current data suggest a potential benefit.
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