Further studies on endocrine factors and the growth and spread of B16 melanoma

An intramuscularly inoculated B16 melanoma line grew or slowly in normal female mice than in either those following oophorectomy and/or estrogen therapy, or in male syngenic C57BL6J mice following orchidectomy and/or estrogen therapy. The number of metastases in estrogen-treated mice was higher than in the other groups.