Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adrenal dysfunction: test strategies for diagnosis

M D Burke

    Postgraduate Medicine
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Diagnosing Cushing's syndrome involves measuring urinary free cortisol and performing a dexamethasone suppression test. Plasma ACTH levels help differentiate its subtypes, while other tests diagnose virilization and adrenal insufficiency.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Editor's Mail.

    Postgraduate medicine·2016
    Same author

    Screening of λgt11 cDNA Libraries Using Monoclonal Antibodies.

    Methods in molecular biology (Clifton, N.J.)·2012
    Same author

    Screening of λgt11 cDNA Libraries Using Monoclonal Antibodies.

    Methods in molecular biology (Clifton, N.J.)·2012
    Same author

    Nutrient removal in a sequencing batch biofilm reactor (SBBR) using a vertically moving biofilm system.

    Environmental technology·2004
    Same author

    The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.

    British journal of cancer·2002
    Same author

    Triggered enzymatic degradation of a water-soluble polymer solution using a novel inhibitor.

    Biomacromolecules·2001
    Same journal

    CV risk: if you aren't testing ACR, you aren't seeing the full picture.

    Postgraduate medicine·2026
    Same journal

    Anti-TNF-induced vasculitis: analysis of data from the French national pharmacovigilance database.

    Postgraduate medicine·2026
    Same journal

    Relationship of serum nesfatin-1 levels with body mass index and c-reactive protein in patients presenting to the emergency department with epileptic seizures.

    Postgraduate medicine·2026
    Same journal

    Clinical pharmacokinetics of colistimethate sodium and formed colistin in patients with renal impairment or on dialysis modalities: a systematic review and implications for precision dosing.

    Postgraduate medicine·2026
    Same journal

    The role of type D personality in pregnancy symptom severity, functional limitations, and maternal ambivalence.

    Postgraduate medicine·2026
    Same journal

    Operational and demographic predictors of leaving without being seen in a high-volume tertiary emergency department: a five-year case-control study.

    Postgraduate medicine·2026
    See all related articles

    Area of Science:

    • Endocrinology
    • Diagnostic Medicine

    Background:

    • Cushing's syndrome and related endocrine disorders require accurate diagnostic methods.
    • Distinguishing between different subtypes of Cushing's syndrome is crucial for effective treatment.

    Purpose of the Study:

    • To outline the optimal diagnostic tests for detecting and differentiating various endocrine conditions.
    • To provide a guide for selecting the most appropriate laboratory investigations.

    Main Methods:

    • Measurement of urinary free cortisol.
    • 1-mg overnight dexamethasone suppression test.
    • Plasma adrenocorticotropic hormone (ACTH) level determination.
    • Urinary 17-ketosteroid and plasma testosterone assays.
    • Short ACTH stimulation testing.

    Related Experiment Videos

    Main Results:

    • Urinary free cortisol and dexamethasone suppression tests are key for Cushing's syndrome detection.
    • Plasma ACTH levels are essential for differentiating Cushing's syndrome subtypes.
    • Urinary 17-ketosteroids and plasma testosterone aid in identifying the cause of virilization.
    • Short ACTH stimulation is the preferred test for adrenal insufficiency.

    Conclusions:

    • Specific biochemical tests are recommended for the accurate diagnosis and subtyping of endocrine disorders.
    • The selection of diagnostic tests should be guided by the clinical presentation to ensure efficiency and accuracy.