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Dopamine depletion by 6-hydroxydopamine prevents conditioned taste aversion induced by methylamphetamine but not
Pharmacology, Biochemistry, and Behavior
|January 1, 1981
Abstract:
Specific lesions of the central dopaminergic system produced by intraventricular injections of 6-hydroxydopamine with pargyline and desmethylimipramine pretreatment significantly attenuated conditioned taste aversions to a sweetened-condensed milk solution induced by methylamphetamine. Identically treated rats formed an aversion to the milk solution when lithium chloride was utilized. These results suggest that the methylamphetamine-induced aversion is dependent upon intact dopaminergic neurons.