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Related Experiment Videos

Bu and SV: two closely related B-locus specificities

I Schreuder, H G Nieman, G J Laundy

    Tissue Antigens
    |August 1, 1980
    PubMed
    Summary

    Researchers investigated the "Bu" and "SV" specificities, closely related to HLA antigens B15/Bw21/Bw35. These antigens, found in about 1% of Caucasians, may be linked to specific HLA types and are associated with B15 variants common in Negroid populations.

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    Area of Science:

    • Immunogenetics
    • HLA antigen research
    • Serology

    Background:

    • The B15/Bw21/Bw35 antigen groups encompass specificities with complex serological relationships.
    • Previous studies have suggested potential associations and variations within these HLA antigen groups, particularly in different ethnic populations.

    Purpose of the Study:

    • To investigate and characterize the distinct serological specificities designated as "Bu" and "SV", which are related to the HLA-B15/Bw21/Bw35 antigens.
    • To determine the phenotypic frequency and potential associations of the "Bu" and "SV" specificities within Caucasian populations.
    • To explore the relationship of "Bu" and "SV" to other known HLA antigens and to variants prevalent in Negroid populations.

    Main Methods:

    • Independent and collaborative serological studies were conducted in Bristol and Leiden, involving the exchange of sera and cells.

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  • Phenotypic frequencies of the "Bu" and "SV" specificities were analyzed in Dutch and English Caucasian populations.
  • Association studies were performed to explore potential links between "Bu" and "SV" and known HLA-A and HLA-C locus antigens.

    • Main Results:

    • Evidence suggests that "Bu" and "SV" represent discrete, albeit closely related, antigens.
    • The combined phenotype frequency of "Bu" and "SV" was found to be approximately 1% in Dutch and English Caucasians.
    • A potential association between the "SV" specificity and the HLA-Aw36 antigen was observed.
    • No clear haplotype or phenotypic association was definitively established for the "Bu" specificity with any HLA-A or HLA-C locus antigen.
    • Both "Bu" and "SV" appear to be related to a variant of HLA-B15 that is reportedly common in Negroid populations.

    Conclusions:

    • The "Bu" and "SV" specificities are likely distinct HLA antigens closely related to the B15/Bw21/Bw35 group.
    • These antigens occur at a low frequency (approximately 1%) in Caucasian populations.
    • "SV" may be associated with HLA-Aw36, while "Bu" lacks a clear association with HLA-A or HLA-C antigens.
    • "Bu" and "SV" show a relationship to HLA-B15 variants found in Negroid populations, highlighting potential ethnic variations in HLA antigen expression.