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Fibrinolytic activity during pregnancy
The Tohoku Journal of Experimental Medicine
|November 1, 1980
Summary
Pregnancy accelerates fibrinolytic activity, indicated by decreased plasmin inhibitor and increased fibrin/fibrinogen degradation products (FDP). This local uterine event contrasts with systemic hypofibrinolysis in normal pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Physiology
Background:
- Pregnancy is generally associated with diminished fibrinolytic activity.
- However, increased fibrin/fibrinogen degradation products (FDP) suggest accelerated fibrinolysis during pregnancy, creating conflicting observations.
Purpose of the Study:
- To clarify the conflicting findings on fibrinolytic activity during pregnancy.
- To investigate the roles of alpha-2-plasmin inhibitor and FDP as sensitive indicators of fibrinolytic activity.
Main Methods:
- Studied alpha-2-plasmin inhibitor and FDP levels during pregnancy.
- Compared FDP levels in uterine vein blood versus arterial blood.
Main Results:
- Observed a decrease in plasmin inhibitor and an increase in FDP during pregnancy.
- Found higher FDP levels in uterine vein blood compared to arterial blood.
Conclusions:
- Pregnancy accelerates fibrinolytic activity, evidenced by decreased plasmin inhibitor and increased FDP.
- Accelerated fibrinolysis appears to be a local event in the uterus.
- Systemic blood in normal pregnancy remains hypofibrinolytic.