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Renal toxicity of aspirin to rats pre-treated with ethinyl oestradiol
Toxicology Letters
|March 1, 1980
Abstract:
Castrated rats receiving aspirin at a dose level of 1000 mg/kg showed necrosis of the proximal convoluted tubules, similar to that seen in female rats, and the extent of this lesion was increased by oestrogen pre-treatment. Urinary gamma-glutamyl transpeptidase activity was a useful indicator of the necrotic changes induced.