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Multifocal myxedema and mixed thyroid neoplasm in a dog
Veterinary Pathology
|January 1, 1981
Summary
This study details a rare case of a dog with extensive skin masses caused by myxedematous tissue accumulation and concurrent thyroid tumors. The findings highlight complex neoplastic and degenerative conditions in a canine patient.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
Background:
- Old English Sheepdog presented with multiple bilateral tumor-like masses and digital pad swelling.
- Histopathological examination revealed myxedematous connective tissue accumulation in the dermis.
Observation:
- Abundant glycosaminoglycan-rich ground substance confirmed via special stains (colloidal iron, toluidine blue, alcian blue).
- Concurrent thyroid gland tumors: mixed follicular-compact cellular carcinoma (left) and anaplastic mesenchymal tumor with cartilaginous elements and follicular-compact carcinoma (right).
Findings:
- Mesenchymal areas showed cellular atypia and aberrant mitotic figures, suggesting malignancy.
- Pulmonary metastases were identified, originating solely from the thyroid carcinoma.
- Clinical signs of thyroid dysfunction were absent, despite a slightly below-normal resting serum T-4 level.
Implications:
- This case illustrates a complex interplay of neoplastic and degenerative processes in a canine patient.
- Highlights the importance of thorough histopathological evaluation for accurate diagnosis of complex masses.
- Underscores potential for aggressive thyroid carcinoma with metastases, even with subclinical or absent thyroid dysfunction.