Congenital defects of squirrel monkeys (Saimiri sciureus)

Area of Science:

• Veterinary Pathology
• Primate Medicine
• Developmental Biology

Background:

• Congenital anomalies in non-human primates can impact research validity.
• Previous studies suggest a notable prevalence of birth defects in squirrel monkeys.

Purpose of the Study:

• To document and characterize congenital defects in a cohort of squirrel monkeys.
• To assess the incidence of anomalies in aborted, stillborn, and neonatal squirrel monkeys.

Main Methods:

• Necropsy of 27 aborted/stillborn and 25 neonatal squirrel monkeys over two years.
• Detailed examination and recording of all observed congenital abnormalities.

Main Results:

• Nine distinct congenital defects were identified in six animals.
• Observed anomalies included diaphragmatic hypoplasia, renal aplasia, cleft lip/palate, hydrocephalus, and campomelic syndrome.
• Incidence rates were 4.9% of total births and 11.5% of nonsurviving births.

Conclusions:

• The observed incidence of congenital defects in squirrel monkeys is significant.
• Findings are consistent with previous reports, underscoring the need for awareness in primate breeding programs.