[Study of the utero-placental perfusion by means of a circulation model (author's transl)]

The radioactivity time curves recorded over the utero-placental unit after application of 250 microCi 113mIn-transferrin may be regarded as the sum of various functional factors and morphological components. In order to be able to evaluate the influence of one single factor on the course of the curve in-vitro experiments were performed using a circulation model and an artificial placenta designed by the authors. The experiments confirmed that a gradual rise of flow resistance - equal to that present in cases of EPH-gestosis - results in a gradual reduction of the flow. By simultaneously raising the systolic pressure the values recorded got normal lowering the systolic pressure to values equal to those observed in hypotension a gradual drop of the flow was evoked. The results show that a rise of flow resistance or a drop of the mean arterial pressure results in curves as seen in case of reduced maternal blood supply to the placenta.