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[Thrombolytic therapy with special reference to old venous occlusions]
Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|November 15, 1980
Summary
This study evaluated streptokinase (Awelysin) for thrombolysis in 53 patients. Results show significant recanalization and symptom relief even in late-stage thromboses, comparable to early-stage treatments.
Area of Science:
- Vascular Surgery
- Pharmacology
- Medical Imaging
Background:
- Thrombolytic therapy is crucial for managing thrombotic events.
- Limited data exists on the efficacy of late-stage thrombolysis.
Purpose of the Study:
- To assess the effectiveness of streptokinase (Awelysin) in thrombolysis, particularly in late-stage thromboses.
- To evaluate recanalization rates and clinical outcomes following thrombolytic treatment.
Main Methods:
- Conducted 53 thrombolysis procedures using streptokinase (Awelysin).
- Included 46 patients with phlebothrombosis, with a focus on 32 late thromboses.
- Performed 7 arterial lysis procedures.
- Detailed analysis of dosage, side effects, and complications.
Main Results:
- Achieved complete or extensive recanalization in 65.5% of patients, including those with older thromboses.
- Attained a 71% clinical symptom-free state post-therapy.
- Findings in late lysis showed no essential deviations compared to early lysis reports.
Conclusions:
- Streptokinase (Awelysin) is effective for thrombolysis, yielding significant recanalization and symptom improvement even in late-stage thromboses.
- Late-stage thrombolysis with streptokinase demonstrates comparable outcomes to early-stage treatment.
- The study supports the use of streptokinase for a broad range of thrombotic conditions.