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[MBCK and infarct size (author's transl)]

R von Essen, M Schlicht, W Merx

    Zeitschrift Fur Kardiologie
    |November 1, 1980
    PubMed
    Summary

    Calculating infarct size using creatine kinase (CK) and myoglobin-bound creatine kinase (MBCK) serum activity showed a moderate correlation. Variations in MBCK levels explain the discrepancies in infarct size estimations between the two methods.

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    Area of Science:

    • Biochemistry
    • Cardiology
    • Clinical Chemistry

    Context:

    • Acute myocardial infarction (AMI) diagnosis and prognosis rely on accurate infarct size estimation.
    • Creatine kinase (CK) and its isoenzymes, like myoglobin-bound creatine kinase (MBCK), are biomarkers for myocardial injury.
    • Assessing infarct size using serum enzyme activity requires understanding the behavior of these enzymes post-infarction.

    Purpose:

    • To evaluate the correlation between infarct size calculated from serum CK activity (CK-IG) and MBCK activity (MBCK-IG) in patients with acute myocardial infarction.
    • To investigate the factors contributing to discrepancies in infarct size estimations using CK and MBCK.
    • To assess the reliability of MBCK as a sole marker for infarct size calculation.

    Summary:

    • In 128 acute myocardial infarction patients, infarct size was calculated using CK and MBCK serum activity with individual fractional decay rates.
    • A moderate correlation (r=0.65) was observed between CK-IG and MBCK-IG, with slight improvement upon excluding resuscitated patients (r=0.69).
    • Discrepancies are attributed to wide variations (4.7-21.2%) in the serum MBCK to CK percentage, deviating from the assumed myocardial 14% constant.

    Impact:

    • Highlights the limitations of using MBCK alone for infarct size calculation due to variable serum enzyme ratios.
    • Suggests that the assumption of a constant MBCK percentage in serum is invalid, impacting the accuracy of infarct size estimations.
    • Underscores the need for refined methodologies or consideration of enzyme variations when calculating infarct size from serum biomarkers.

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