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Absorbable material in vascular prostheses: a new device

S Bowald, C Busch, I Eriksson

Acta Chirurgica Scandinavica

|January 1, 1980

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This study shows pig aortic tissue can regenerate and replace polyglactin mesh grafts with new vessel walls. Composite grafts, combining resorbable and non-resorbable materials, formed prostheses with endothelialized tissue linings.

Area of Science:

Vascular surgery
Biomaterials science
Regenerative medicine

Background:

Aortic bypass grafting is crucial for treating cardiovascular diseases.
Evaluating novel graft materials is essential for improving surgical outcomes.
Understanding tissue regeneration around synthetic grafts is key.

Purpose of the Study:

To investigate the biological response to different graft materials in pig aortas.
To assess the regenerative capacity of aortic tissue with various biomaterials.
To evaluate composite grafts combining resorbable and non-resorbable components.

Main Methods:

End-to-side anastomosis of bypass grafts in the descending aorta of 20 pigs.
Utilized polyglactin 910 (Vicryl) mesh, PTFE (Impra), and Dacron grafts, both alone and in composite configurations.

Related Experiment Videos

Light microscopy was employed to study the biological processes at the graft site.

Main Results:

Pig aortic tissue demonstrated significant regenerative capacity, replacing 7-15 cm polyglactin mesh grafts with endothelialized tissue.
Composite grafts (groups II and IV) resulted in prostheses featuring an internal layer of endothelialized arterial tissue.
Different combinations of polyglactin, PTFE, and Dacron influenced graft integration and tissue response.

Conclusions:

The inherent regenerative capacity of pig aortic tissue supports the integration of resorbable mesh grafts.
Composite vascular grafts can achieve an endothelialized lining, mimicking native arterial tissue.
This research provides insights into biomaterial selection for aortic reconstruction.