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Diazepam under hyperbaric conditions in rats

L Gran, R Coggin, P B Bennett

    Acta Anaesthesiologica Scandinavica
    |October 1, 1980
    PubMed
    Summary
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    Diazepam prevented high-pressure convulsions in rats, showing a pressure reversal effect on the loss of righting reflex. This indicates diazepam mitigates High Pressure Nervous Syndrome (HPNS) symptoms.

    Area of Science:

    • Physiology
    • Pharmacology
    • Marine Biology

    Background:

    • High pressure environments can induce physiological stress.
    • High Pressure Nervous Syndrome (HPNS) is a concern for deep-sea exploration.
    • Understanding drug effects under pressure is crucial.

    Purpose of the Study:

    • To investigate the effects of diazepam on rats exposed to high pressure.
    • To assess diazepam's impact on the loss of righting reflex.
    • To determine if diazepam prevents or reduces High Pressure Nervous Syndrome (HPNS) symptoms.

    Main Methods:

    • Adult rats were exposed to 90 ATA with oxygen/helium.
    • Diazepam's effect on the righting reflex was measured.
    • Control groups were maintained at 1 ATA.

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    Main Results:

    • A significant pressure reversal of diazepam's effect on righting reflex was observed.
    • Diazepam prevented high helium pressure-induced convulsions.
    • Symptoms associated with High Pressure Nervous Syndrome (HPNS) were reduced by diazepam.

    Conclusions:

    • Diazepam exhibits a pressure-dependent effect on the righting reflex.
    • Diazepam is effective in preventing convulsions and reducing HPNS symptoms under high pressure.
    • These findings have implications for managing physiological effects in extreme environments.