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Multiple sclerosis in North-West India

J S Chopra, K Radhakrishnan, B B Sawhney

    Acta Neurologica Scandinavica
    |November 1, 1980
    PubMed
    Summary
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    This study on multiple sclerosis (MS) in North-West India found distinct clinical features, including common visual impairment and a higher incidence of neuromyelitis optica (Devic's syndrome). Cerebrospinal fluid analysis showed limited correlation with MS type or severity.

    Area of Science:

    • Neurology
    • Clinical Neuroscience
    • Epidemiology

    Background:

    • Multiple sclerosis (MS) presents with diverse clinical manifestations globally.
    • Understanding regional variations in MS presentation is crucial for accurate diagnosis and management.
    • Previous studies from Asia suggest unique epidemiological and clinical patterns of MS.

    Purpose of the Study:

    • To describe the clinical features of multiple sclerosis in a North-West Indian population.
    • To compare these features with those reported in other Asian and global series.
    • To investigate potential correlations between cerebrospinal fluid (CSF) abnormalities and MS characteristics.

    Main Methods:

    • Retrospective analysis of 54 patients diagnosed with multiple sclerosis in North-West India.

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  • Inclusion of pathologically confirmed cases and patients meeting criteria for neuromyelitis optica (Devic's syndrome).
  • Clinical data collection focusing on onset symptoms, neurological involvement, and disability, alongside CSF analysis.

    • Main Results:

    • The study identified specific clinical characteristics in Indian MS patients, including frequent visual impairment at onset.
    • Predominant involvement of optic nerves and spinal cord was observed.
    • A higher incidence of classical neuromyelitis optica (Devic's syndrome) was noted compared to some other regions.
    • Cerebrospinal fluid abnormalities showed limited correlation with MS type, attack duration, or disability, with a possible link between colloidal gold reaction patterns and MS type.

    Conclusions:

    • Multiple sclerosis in North-West India exhibits distinct clinical features, aligning with other Asian reports.
    • Visual impairment and optic nerve/spinal cord involvement are common presenting symptoms.
    • Neuromyelitis optica (Devic's syndrome) appears to have a higher incidence in this population.
    • Cerebrospinal fluid findings have limited predictive value for MS type or severity in this cohort, except for colloidal gold reactions.