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Amyloidosis in systemic lupus erythematosus
The American Journal of Medicine
|February 1, 1981
Summary
Amyloidosis, a complication in rheumatologic diseases, involves amyloid A protein. This case study highlights amyloid A protein in a patient with systemic lupus erythematosus (SLE), suggesting its consideration in SLE-related proteinuria.
Area of Science:
- Rheumatology
- Nephrology
- Pathology
Background:
- Amyloidosis is a known complication in rheumatologic diseases, typically involving amyloid A protein.
- Systemic lupus erythematosus (SLE) is rarely associated with amyloidosis.
Observation:
- A patient with SLE presented with amyloidosis.
- Renal tissue analysis confirmed amyloid deposits composed of amyloid A protein.
- Elevated serum amyloid A protein concentrations were observed.
Findings:
- This case demonstrates amyloid A protein as the fibrillar component in a patient with SLE and amyloidosis.
- Previous literature described only four cases of SLE-associated amyloidosis, without protein analysis.
Implications:
- Amyloidosis should be considered in the differential diagnosis of proteinuria in SLE patients.
- Further research into the mechanisms and prevalence of amyloid A protein amyloidosis in SLE is warranted.