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Leukocyte chemotaxis in recurrent polyserositis (familial Mediterranean fever)
The American Journal of the Medical Sciences
|January 1, 1981
Abstract:
Polymorphonuclear leukocyte chemotaxis was investigated in 35 patients with recurrent polyserositis during attacks and during spontaneous or colchicine-induced remissions. Chemotaxis was found to be unchanged in the attack-free period in untreated patients, increased by about 50% during attacks, and decreased by about 50% during colchicine treatment.
Insights
Polymorphonuclear leukocyte chemotaxis increases during attacks in polyserositis patients but decreases with colchicine treatment. Chemotaxis remains unchanged in untreated patients during remission periods.
Area of Science:
- Immunology
- Rheumatology
Background:
- Recurrent polyserositis is an inflammatory condition.
- Polymorphonuclear leukocyte (PMN) chemotaxis plays a role in inflammation.
Purpose of the Study:
- To investigate polymorphonuclear leukocyte (PMN) chemotaxis in patients with recurrent polyserositis.
- To assess changes in PMN chemotaxis during disease attacks and remissions, including those induced by colchicine.
Main Methods:
- Studied 35 patients with recurrent polyserositis.
- Measured PMN chemotaxis during disease attacks.
- Measured PMN chemotaxis during spontaneous and colchicine-induced remissions.
Main Results:
- PMN chemotaxis was unchanged in untreated patients during remission.
- PMN chemotaxis increased by approximately 50% during attacks.
- PMN chemotaxis decreased by approximately 50% during colchicine treatment.
Conclusions:
- Polymorphonuclear leukocyte (PMN) chemotaxis is significantly altered in recurrent polyserositis.
- Disease activity (attacks) is associated with increased PMN chemotaxis.
- Colchicine treatment effectively reduces PMN chemotaxis in these patients.