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Related Experiment Videos

Concentration of cefaclor in human prostatic tissue

R P Smith, G P Schmid, A L Baltch

    The American Journal of the Medical Sciences
    |January 1, 1981
    PubMed
    Summary

    This study measured cefaclor concentrations in prostate tissue after oral administration. Achieved levels were below the minimum inhibitory concentration for common bacterial prostatitis pathogens.

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    Area of Science:

    • Pharmacology
    • Urology
    • Infectious Diseases

    Background:

    • Bacterial prostatitis remains a challenging condition to treat.
    • Understanding antibiotic penetration into prostatic tissue is crucial for effective therapy.

    Purpose of the Study:

    • To quantify cefaclor concentrations in human prostatic tissue.
    • To assess the potential of cefaclor for treating bacterial prostatitis.

    Main Methods:

    • Ten patients undergoing suprapubic prostatectomy received oral cefaclor (250mg or 500mg).
    • Prostatic tissue and plasma concentrations of cefaclor were measured.
    • Prostate/plasma ratios were calculated to assess drug accumulation.

    Main Results:

    • Average prostatic tissue concentrations were 0.51 ± 0.22 µg/g (250mg) and 0.74 ± 0.67 µg/g (500mg).

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  • Prostate/plasma ratios were approximately 0.7, indicating no significant accumulation.
  • Achieved cefaclor levels were generally below the MIC for common prostatitis pathogens.

    • Conclusions:

    • Oral cefaclor demonstrates limited penetration into prostatic tissue.
    • Therapeutic concentrations for bacterial prostatitis may not be consistently achieved with cefaclor.
    • Further investigation into antibiotic efficacy in prostatitis is warranted.