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In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
The quantitative genetics of disease: ambiguities
American Journal of Medical Genetics
|January 1, 1980
Abstract:
Here I review briefly some terms appropriate to the formal discussion of the genetics of disease. The motive for writing is that at least three kinds of participating experts are involved: pathologists, geneticists, and statisticians. Not only may some of the terms used in one field be unfamiliar to experts from another, the same term may be used in diverse ways among, or even within, fields. Such ambiguity may create illusory understanding or even frank confusion.
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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...

