Computer-assisted analysis of the therapy of acute salpingitis

Isolation rates of microorganisms recovered by culdocentesis and/or laparoscopy in nine studies of salpingitis were multiplied by the proportions of each species which would be inhibited in vitro at peak and 1/2 peak serum levels of 13 antimicrobial drugs to yield a prediction of efficacy for the drugs. Efficacies of several hundred combinations of two and three of these drugs were estimated also. Some pairs of oral drugs were predicted to be as efficacious as some parenteral regimens of two or three drugs now in use. The predictions with this model parallel the results of some recently reported studies of therapy for salpingitis, and the model may prove to be a useful tool for future trials and therapy.