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Hyperprolactinemia--a significant factor in female infertility

J V Kredentser, C F Hoskins, J Z Scott

    American Journal of Obstetrics and Gynecology
    |February 1, 1981
    PubMed
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    Hyperprolactinemia, or elevated prolactin levels, is common in infertile women. This condition is more frequently observed when irregular periods or milky nipple discharge (galactorrhea) are also present.

    Area of Science:

    • Reproductive endocrinology
    • Clinical diagnostics

    Background:

    • Hyperprolactinemia is a condition characterized by elevated serum prolactin levels.
    • Prolactin plays a role in reproductive function, and its dysregulation can impact fertility.
    • The incidence and clinical associations of hyperprolactinemia in infertile women warrant further investigation.

    Purpose of the Study:

    • To determine the incidence of hyperprolactinemia in referred infertile women.
    • To assess the association between hyperprolactinemia and abnormal menstrual function.
    • To examine the relationship between hyperprolactinemia and the presence of galactorrhea.

    Main Methods:

    • A prospective study design was employed.
    • 113 referred infertile patients were included in the study cohort.
    Keywords:
    AmenorrheaBiologyCentral Nervous SystemCentral Nervous System EffectsDiseasesEndocrine SystemGalactorrheaGonadotropinsGonadotropins, PituitaryHormonesIncidenceInfertilityMeasurementMenstruationMenstruation DisordersMetrorrhagiaPhysiologyPituitary HormonesProlactin--analysisProspective StudiesPuerperal DisordersReproductionResearch MethodologyStudies

    Related Experiment Videos

  • Serum prolactin levels were measured, and patients were assessed for menstrual function and galactorrhea.

    • Main Results:

    • Elevated serum prolactin levels (hyperprolactinemia) were identified in 22 out of 113 (19.5%) infertile patients.
    • A significant proportion of patients with hyperprolactinemia also presented with abnormal menstrual function or galactorrhea.
    • Five patients (4.4%) with hyperprolactinemia had neither abnormal menstrual function nor galactorrhea, indicating isolated hyperprolactinemia.

    Conclusions:

    • Hyperprolactinemia is a common endocrine disorder found in infertile women.
    • The presence of galactorrhea and/or menstrual dysfunction increases the likelihood of hyperprolactinemia in infertile populations.
    • Screening for hyperprolactinemia is valuable in the evaluation of infertile women, particularly those with associated symptoms.