[Haemodilution and duration of action of muscle relaxants (author's transl)]

As indicated by time-effect diagrams the duration of action of the ED90 of succinylcholine (0.3 mg/kg), pancuronium (0.033 mg/kg), and tubocurarine (0.21 mg/kg) was prolonged following preoperative normovolemic haemodilution. This influence is assumed to be due to a lower protein binding and cholinesterase activity, to an increase of cardiac output and muscle perfusion and to a higher occupancy of the receptor at the motor endplate by muscle relaxants.