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Updated: Sep 13, 2026

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach
Published on: June 11, 2017
[Long lasting anaesthesia. Study among the children (author's transl)]
Abstract:
In five years 14 children aged 1 to 15 underwent long lasting anesthesia (9,6 +/- 1,7 hours), excluding cardiac and neuro-surgery. These anesthesias, which are seldom performed are essentially used for the correction of congenital malformations of the cephalic pole (9 patients). Two types of anesthesia were used: neuroleptanalgesia (11 patients), enflurane and narcotic (3 patients). In addition to the usual monitoring in pediatric anesthesiology the insertion of a catheter in the radial artery proved essential. Temperature never went below 35 degrees C. In 8 cases blood loss was higher than the patient blood volume. The average preoperative perfusion was 9,4 +/- 5,4 ml/kg/heure.
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