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[Measurement of CK-BB isoenzyme after cardiac surgery (author's transl)]
Insights
Serum creatine kinase BB isoenzyme (CK-BB) levels increase after cardiac surgery, particularly with complex procedures. This rise may not always indicate central nervous system damage, highlighting its limited specificity.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Neurology
Context:
- Cardiac surgery with cardiopulmonary bypass is a complex procedure.
- Postoperative monitoring of biochemical markers is crucial.
- Creatine kinase BB isoenzyme (CK-BB) is a marker often associated with the central nervous system.
Purpose:
- To investigate the changes in serum CK-BB levels in patients undergoing cardiac surgery.
- To determine the correlation between CK-BB levels and factors like anesthesia duration and surgical complexity.
- To assess the specificity of elevated CK-BB as an indicator of central nervous system damage in this context.
Summary:
- Serum CK-BB levels were measured in 135 patients (infants, children, adults) after cardiac surgery with cardiopulmonary bypass.
- Anesthesia duration did not significantly influence CK-BB levels.
- Increased CK-BB concentrations were associated with the severity and complexity of surgical procedures, but not consistently with clinical cerebral damage.
Impact:
- Elevated serum CK-BB levels post-cardiac surgery may not be a specific marker for central nervous system lesions.
- Findings suggest that other factors, beyond CNS damage, contribute to CK-BB elevation.
- This research aids in the accurate interpretation of CK-BB as a biomarker in postoperative cardiac surgery patients.
Abstract:
We measured the BB isoenzyme of creatine kinase in the serum of 135 patients following cardiac surgery with cardiopulmonary bypass: 64 infants, 48 children and 23 adults, 56 of them have had, at least, one positive result. The duration of anaesthesia do not have any influence; we have found the same proportion of positive results in the two groups with anaesthesia less or more than 8 hours. Severity and complexity of the surgical procedure induce the CK-BB increase. In many cases, a high serum concentration of CK-BB is not related to clinical cerebral damage. Under this circumstances, it is possible that the rise in CK-BB concentration is not specific of central nervous system lesion.