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Rapid, shallow ventilatory pattern during exercise after histamine, bronchopprovocation

M J Hernandez, B L Bradley, W C Miller

    Annals of Allergy
    |February 1, 1981
    PubMed
    Summary
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    Inhaled histamine caused rapid, shallow breathing during exercise in healthy individuals, but overall ventilation and oxygen intake remained stable. This suggests compensatory mechanisms despite increased airway resistance.

    Area of Science:

    • Respiratory Physiology
    • Exercise Physiology
    • Pharmacology

    Background:

    • Histamine is a known bronchoconstrictor that increases specific airway resistance.
    • Understanding the ventilatory response to bronchoconstriction during rest versus exercise is crucial for respiratory health assessment.

    Purpose of the Study:

    • To investigate the ventilatory response to inhaled histamine-induced bronchoconstriction at rest and during steady-state exercise in normal subjects.
    • To determine if exercise alters the breathing pattern or overall ventilation when specific airway resistance is elevated.

    Main Methods:

    • Healthy subjects inhaled histamine to double specific airway resistance.
    • Ventilatory parameters (breathing rate, tidal volume, ventilation) and oxygen consumption were measured at rest and during steady-state exercise.

    Related Experiment Videos

  • Breathing patterns were analyzed before and after histamine challenge.

    • Main Results:

    • No significant changes in ventilation were observed at rest following histamine inhalation.
    • During exercise, subjects exhibited a shift towards a rapid, shallow breathing pattern after histamine exposure.
    • Despite the altered breathing pattern and increased airway resistance, overall ventilation and oxygen consumption remained unchanged during exercise.

    Conclusions:

    • Healthy individuals can maintain resting ventilation despite histamine-induced bronchoconstriction.
    • During exercise, a compensatory rapid, shallow breathing pattern emerges in response to increased airway resistance, preserving overall ventilation and oxygen consumption.
    • This suggests effective respiratory system regulation during exercise even with moderate bronchoconstriction.