Isobaric 0.5% bupivacaine in spinal anaesthesia
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Updated: Oct 12, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Abstract:
A study of 240 consecutive patients who were given spinal anaesthesia with isobaric 0.5% bupivacaine is presented. 215 patients had various orthopaedic operations; 89 patients underwent a total hip-prosthesis operation. Mean age was 62 years (22-88). Duration of surgery was 79 +/- 35 min (mean +/- SD) and analgesia always outlasted the surgery. The follow-up time in the recovery room was 416 +/- 139 min (170-570 min) and 31% of patients needed no analgesics during this time. No serious complications were observed. The incidence of hypotension was exceptionally high (30%) possibly due to the fact that no fluid preloading was used but it was easily controlled by etilefrine and atropine.
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