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Fast and Accurate Exhaled Breath Ammonia Measurement

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Collection of breath for hydrogen estimation

A J Gardiner, M J Tarlow, I T Sutherland

Archives of Disease in Childhood

|February 1, 1981

Summary

Breath hydrogen testing aids in diagnosing pediatric gastrointestinal issues like sugar malabsorption. Several collection methods are adequate, with Rahn-Otis samplers recommended for infants and Haldane-Priestley tubes for older children.

Area of Science:

Pediatric Gastroenterology
Diagnostic Testing

Background:

Breath hydrogen testing is crucial for diagnosing pediatric gastrointestinal disorders.
Common applications include identifying sugar malabsorption, assessing transit time, and detecting small-bowel bacterial overgrowth.

Purpose of the Study:

To compare the efficacy and acceptability of various breath hydrogen collection techniques in children.
To determine the most suitable methods for different age groups.

Main Methods:

Four breath collection techniques (postnasal catheter, nasal prong, Rahn-Otis end-tidal sampler, 'Wiggins's blowout') were evaluated against the Haldane-Priestley tube.
Breath samples were collected from 3 adults after lactulose loads to assess hydrogen excretion variability.

Main Results:

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Variability between different breath hydrogen assay techniques was found to be less than the inherent variability within a single technique.
All tested methods demonstrated adequacy for breath hydrogen collection.

Conclusions:

The Rahn-Otis end-tidal sampler is recommended for young infants and children.
The Haldane-Priestley tube is suggested for older children due to higher acceptability.
Both methods provide reliable breath hydrogen collection for pediatric gastrointestinal investigations.