Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age as a variable in acetaminophen overdose

R G Peterson, B H Rumack

    Archives of Internal Medicine
    |February 23, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Accidental acetaminophen ingestion in young children rarely causes toxicity. Even with toxic plasma levels, acetylcysteine treatment showed minor liver function abnormalities in children.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.

    Human & experimental toxicology·2018
    Same author

    A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.

    Clinical toxicology (Philadelphia, Pa.)·2014
    Same author

    Submaxillary duct and gland stones; report of a case.

    Journal of oral surgery·2010
    Same author

    Ranula (cystic tumor); report of case.

    Journal of oral surgery·2010
    Same author

    Bilateral osteotomy of the mandibular rami for correction of prognathism in an edentulous mouth; report of case.

    Journal of oral surgery·2010
    Same author

    Compound composite odontome of the mandible.

    Journal of oral surgery·2010
    Same journal

    Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

    Archives of internal medicine·2017
    Same journal

    Occult Carbon Monoxide Poisoning-Reply.

    Archives of internal medicine·2017
    Same journal

    Acquired Immune Deficiency Syndrome-Reply.

    Archives of internal medicine·2017
    Same journal

    Heparin Side Effects-Reply.

    Archives of internal medicine·2017
    Same journal

    Humanizing primary care medicine begins with stress.

    Archives of internal medicine·2017
    Same journal

    Legend omitted and number misrepresented.

    Archives of internal medicine·2013
    See all related articles

    Area of Science:

    • Pediatrics
    • Toxicology
    • Pharmacology

    Background:

    • Acetaminophen overdose in children can lead to severe hepatotoxicity.
    • Accidental ingestions are common in young children, but severe outcomes are infrequent.

    Purpose of the Study:

    • To evaluate acetaminophen toxicity and the efficacy of acetylcysteine in pediatric ingestions.
    • To assess liver function and plasma acetaminophen levels in children following accidental overdose.

    Main Methods:

    • Retrospective review of 17 pediatric acetaminophen ingestions.
    • Measurement of plasma acetaminophen levels and liver function tests.
    • Treatment with acetylcysteine in cases with toxic plasma levels.

    Main Results:

    Related Experiment Videos

    • Five children had toxic plasma acetaminophen levels and received acetylcysteine treatment.
    • No severe liver damage was observed in treated children, regardless of treatment delay (up to 20 hours).
    • Minor liver function abnormalities were transient in treated patients.

    Conclusions:

    • Acetaminophen overdose in young children is often associated with less severe outcomes than in adults.
    • Acetylcysteine is effective in preventing severe hepatotoxicity in pediatric acetaminophen ingestions, even when initiated late.