Infiltrating salivary duct carcinoma. A clinicopathologic study of five cases

The clinicopathologic features of five cases of salivary gland carcinoma characterized by the presence of intraductal components of the carcinomatous process were studied and compared with those of other types of salivary gland carcinoma. The term "infiltrating salivary duct carcinoma" seems to be appropriate for this type of tumor because of its morphologic resemblance to the infiltrating ductal carcinomas of the breast. Its biologic behavior is highly aggressive; the metastatic and tumor-related death rates were 75% and 73%, respectively.