Gap junctions in laryngeal carcinoma

The ultrastructural morphology of gap junctions in malignant keratinocytes of invasive squamous cell carcinoma of the human larynx was studied by electron microscopy. The ultrastructure of gap junctions in the malignant keratinocytes was similar to the typical intercellular gap junctions described in normal tissues. In human laryngeal carcinoma, however, the gap junctions were noticeably reduced in number as compared to normal epithelia. Spherical intracytoplasmic structures limited by gap junctional membranes were also found. These annular gap junctions arise by invagination of the cell surface membrane. The loss of gap junctions in laryngeal carcinoma is probably one of the many prerequisites which facilitate tumor invasion.