Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental intervertebral disc degeneration: morphologic and proteoglycan changes over time

S J Lipson, H Muir

    Arthritis and Rheumatism
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Structure and stability of proteoglycan aggregates.

    Annals of the rheumatic diseases·2014
    Same author

    The stenosis ratio: a new tool for the diagnosis of degenerative spinal stenosis.

    International journal of surgical investigation·2001
    Same author

    Predictors of surgical outcome in degenerative lumbar spinal stenosis.

    Spine·1999
    Same author

    In vivo evaluation of coralline hydroxyapatite and direct current electrical stimulation in lumbar spinal fusion.

    Spine·1999
    Same author

    Comparison of epidural anaesthesia with ropivacaine 0.5% and bupivacaine 0.5% for caesarean section.

    Canadian journal of anaesthesia = Journal canadien d'anesthesie·1999
    Same author

    The unanticipated difficult airway with recommendations for management.

    Canadian journal of anaesthesia = Journal canadien d'anesthesie·1998
    Same journal

    Proceedings of the Annual Meeting of the American Rheumatism Association.

    Arthritis and rheumatism·2020
    Same journal

    The regional distribution of rheumatologists: what can we do, what should we do?

    Arthritis and rheumatism·2013
    Same journal

    Regional distribution of adult rheumatologists.

    Arthritis and rheumatism·2013
    Same journal

    Clinically significant renal involvement in primary Sjögren's syndrome: clinical presentation and outcome.

    Arthritis and rheumatism·2013
    Same journal

    Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study.

    Arthritis and rheumatism·2013
    Same journal

    Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.

    Arthritis and rheumatism·2013
    See all related articles

    This study details a rabbit model for intervertebral disc degeneration, revealing early cellular changes and altered proteoglycan aggregation. The findings highlight a transient repair attempt followed by progressive degeneration.

    Area of Science:

    • Biomedical Engineering
    • Orthopedics
    • Regenerative Medicine

    Background:

    • Intervertebral disc degeneration (IVDD) is a significant cause of low back pain.
    • Existing animal models often lack detailed biochemical and morphological correlation.
    • A robust model is needed to study IVDD pathogenesis and test interventions.

    Purpose of the Study:

    • To establish and characterize a novel rabbit model of IVDD induced by surgical ventral disc herniation.
    • To correlate the histological and biochemical changes occurring after disc herniation.
    • To investigate the early repair mechanisms in the degenerating disc.

    Main Methods:

    • Surgical ventral disc herniation was performed in rabbits.
    • Histological analysis assessed cellular proliferation and matrix changes.

    Related Experiment Videos

  • Proteoglycan content, aggregation, water, and hyaluronic acid levels were quantified over 200 days.

    • Main Results:

    • Histology showed fibrocartilaginous metaplasia and progressive degeneration within 6 weeks.
    • Proteoglycan aggregation capacity showed transient recovery then declined.
    • Disc water and hyaluronic acid content decreased significantly post-injury.

    Conclusions:

    • The rabbit model effectively replicates key morphological and biochemical features of human IVDD.
    • Early disc degeneration involves altered proteoglycan dynamics and water content.
    • Evidence suggests an early, albeit limited, repair response following disc injury.