Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The primary empty sella syndrome. A case report study (author's transl)]

M Casini, V Bianchi, E Brocchi

    L'Ateneo Parmense. Acta Bio-Medica : Organo Della Societa Di Medicina E Scienze Naturali Di Parma
    |January 1, 1980
    PubMed
    Summary

    Empty sella syndrome, where the pituitary gland flattens, can present with obesity and hyperglycemia. A case report suggests a potential link between this condition and diabetes due to disrupted neurovascular connections.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hybrid Repair for Thoraco-Abdominal Aortic Diseases: Benefits of a Staged Treatment Strategy.

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
    Same author

    Foot-and-mouth disease vaccine quality: A universal test for intact viral capsids based on detection of VP4.

    Vaccine·2025
    Same author

    Very Rapid Improvement in Extended Nitric Oxide Parameters Is Associated With Clinical and Functional Improvement in Patients With Chronic Rhinosinusitis With Nasal Polyps Treated With Dupilumab.

    Journal of investigational allergology & clinical immunology·2023
    Same author

    A recent view about encephalomyocarditis virus circulating in compartmentalised animal population in Northern Italy.

    Scientific reports·2023
    Same author

    Characterization of the O/ME-SA/Ind-2001d foot-and-mouth disease virus epidemic recorded in the Maghreb during 2014-2015.

    Transboundary and emerging diseases·2022
    Same author

    Validation of microscopic magnetochiral dichroism theory.

    Science advances·2021

    Area of Science:

    • Endocrinology
    • Neuroimaging
    • Pathophysiology

    Background:

    • Empty sella syndrome involves subarachnoid space extension into the sella turcica, remodeling it and flattening the pituitary gland.
    • Enlargement of the sella turcica can mimic pituitary tumors, posing diagnostic challenges.
    • While most patients maintain normal pituitary function, approximately 30% experience hypopituitarism.

    Observation:

    • A case report details a male patient presenting with obesity and hyperglycemia.
    • Endocrine evaluations, including TRH, Gn-RH, thyroid hormone levels, Arginine, and metyrapone tests, yielded normal results.
    • Oral glucose tolerance testing (OGTT) indicated maturity-onset diabetes with a glycemia of 160 mg%.

    Findings:

    • This case highlights a rare clinical association between primary empty sella syndrome and diabetes mellitus.

    Related Experiment Videos

  • The endocrine function tests were normal, suggesting the diabetes is not a direct consequence of hypopituitarism.
  • The observed hyperglycemia in the context of empty sella syndrome is not well understood.

    • Implications:

    • The findings suggest a potential, though not fully understood, link between empty sella syndrome and diabetes.
    • Disruption of the normal hypothalamo-pituitary neurovascular connection is hypothesized as a possible mechanism for this association.
    • Further research is warranted to elucidate the pathophysiology of this rare clinical presentation.