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[Gilbert's disease]

M Shein, S Pick

    Boletin Medico Del Hospital Infantil De Mexico
    |November 1, 1980
    PubMed
    Summary

    Gilbert's disease, a hereditary condition causing unconjugated hyperbilirubinemia, is reviewed. This summary covers its types, pathogenesis, diagnosis, and treatment, including two family cases.

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    Area of Science:

    • Hepatology
    • Medical Genetics

    Background:

    • Gilbert's disease is a common hereditary disorder characterized by unconjugated, non-hemolytic hyperbilirubinemia.
    • Its exact incidence is undetermined, but genetic factors are strongly implicated.

    Observation:

    • The review discusses two distinct types of Gilbert's disease.
    • Controversies surrounding the pathogenesis of the disease are explored.

    Findings:

    • Clinical manifestations and diagnostic laboratory studies for Gilbert's disease are detailed.
    • Histopathological findings and treatment options are briefly outlined.

    Implications:

    • Understanding Gilbert's disease pathogenesis is crucial for accurate diagnosis and management.
    • The presentation of two familial cases highlights the hereditary nature of the condition.