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[Renal and hepatic toxicity studies in mice treated with sodium saccharin: breaks in single-stranded DNA]

C F Cesarone, C Bolognesi, L Santi

    Bollettino Della Societa Italiana Di Biologia Sperimentale
    |December 15, 1980
    PubMed

    Insights

    Saccharin treatment in mice increased DNA strand breaks in the kidney and liver. No direct dose-damage relationship was observed, with similar effects across tested doses.

    Area of Science:

    • Toxicology
    • Molecular Biology
    • Genetics

    Context:

    • Investigating the in vivo effects of artificial sweeteners.
    • Assessing potential genotoxicity of saccharin.
    • Evaluating DNA damage in mammalian organs.

    Purpose:

    • To determine the renal and hepatic effects of saccharin exposure.
    • To investigate the relationship between saccharin dose and DNA damage.
    • To quantify DNA strand breaks induced by saccharin.

    Summary:

    • In vivo treatment with saccharin led to increased DNA elutability in mouse kidney and liver.
    • A direct dose-response relationship for DNA damage was not observed.
    • Similar levels of single-stranded DNA breaks were induced across saccharin doses (50, 100, 200 mg/Kg).
    • DNA elutability increased by 130-210% compared to control groups.

    Impact:

    • Highlights potential genotoxic effects of saccharin.
    • Informs risk assessment for artificial sweetener consumption.
    • Suggests further research into mechanisms of saccharin-induced DNA damage.

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