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Processes human umbilical veins as arterial substitutes--evaluation in canine models
Biomaterials
|April 1, 1980
Summary
Two vascular grafts, Dardik-Biograft and Mindich-Bioflow, were implanted in dogs to replace aortic segments. Both provided functional bypasses, but Mindich-Bioflow showed better thromboresistance despite mechanical vulnerability.
Area of Science:
- Biomaterials Science
- Vascular Surgery
- Regenerative Medicine
Background:
- Human umbilical cord veins serve as vessel substitutes for arterial repair and bypass.
- Commercially available grafts include Dardik-Biograft (glutaraldehyde-fixed) and Mindich-Bioflow (ethanol and dialdehyde starch-fixed).
Purpose of the Study:
- To evaluate the performance of Dardik-Biograft and Mindich-Bioflow as abdominal aorta replacements in a canine model.
- To compare graft patency, dimensional stability, anastomosis integrity, microstructure, and thrombus deposition.
Main Methods:
- Canine abdominal aortas were replaced with Dardik-Biograft and Mindich-Bioflow grafts.
- Post-implantation assessment included angiography, scanning electron microscopy, and histology.
- Evaluation focused on patency, dimensional stability, anastomosis, microstructure, suture damage, and thrombus patterns.
Main Results:
- Both graft types maintained functional bypasses for up to 6 months.
- Dardik-Biograft exhibited increased thrombus formation near the anastomosis and sparse cellular development.
- Mindich-Bioflow demonstrated superior thromboresistance but was more susceptible to mechanical damage.
Conclusions:
- Both vascular grafts offer functional bypasses but possess distinct characteristics.
- Mindich-Bioflow presents better thromboresistance, while Dardik-Biograft shows higher thrombus propensity.
- Further research is needed to optimize graft properties for long-term clinical success.