Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reaction time in Parkinson's disease

E V Evarts, H Teräväinen, D B Calne

    Brain : a Journal of Neurology
    |March 1, 1981
    PubMed
    Summary

    Parkinson's disease primarily affects movement time more than reaction time. Movement time is a better indicator of treatment effectiveness, while reaction time studies may reveal more about the disease's underlying motor deficits.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The cardiovascular effects of bromocriptine in Parkinsonism.

    British journal of clinical pharmacology·2012
    Same author

    Parkinsonism-physiology and pharmacology.

    British medical journal·2010
    Same author

    Relation of motor cortex neurons to precisely controlled and ballistic movements.

    Neuroscience letters·2009
    Same author

    Sensory responses in motor cortex neurons during precise motor control.

    Neuroscience letters·2009
    Same author

    German-Canadian family (family A) with parkinsonism, amyotrophy, and dementia - Longitudinal observations.

    Parkinsonism & related disorders·2008
    Same author

    The role of the Lewy body in idiopathic Parkinsonism.

    Parkinsonism & related disorders·2008

    Area of Science:

    • Neurology
    • Movement Disorders
    • Neuroscience

    Background:

    • Parkinson's disease (PD) is a neurodegenerative disorder affecting motor control.
    • Both reaction time (RT) and movement time (MT) are known to be impaired in PD patients.
    • The independent nature of RT and MT impairments in PD requires further investigation.

    Purpose of the Study:

    • To investigate the distinct effects of Parkinson's disease on reaction time (RT) and movement time (MT).
    • To evaluate the utility of different RT tests and MT as objective measures in Parkinson's disease.
    • To explore potential insights into the central motor disorder of PD through RT analysis.

    Main Methods:

    • Comparative analysis of reaction time (RT) and movement time (MT) in individuals with Parkinson's disease.
    • Assessment of simple visual RT, choice RT, and kinaesthetic RT.
    • Evaluation of MT as a potential biomarker for therapeutic efficacy.

    Main Results:

    • Reaction time (RT) prolongation in Parkinson's disease is generally slight.
    • Movement time (MT) shows more substantial and consistent disturbances compared to RT.
    • Simple visual RT, choice RT, and kinaesthetic RT demonstrate similar degrees of impairment, offering no advantage in measuring neurological deficit in parkinsonism.

    Conclusions:

    • Movement time (MT) is a more sensitive indicator of therapeutic response in Parkinson's disease than reaction time (RT).
    • Further research on specific RT paradigms (e.g., involving displacement, velocity, and accuracy programming) is warranted.
    • Understanding RT deficits may offer deeper insights into the pathophysiology of the central motor disorder in Parkinson's disease.

    Related Experiment Videos