Species differences of amobarbital metabolism: dihydroxyamobarbital formation

Amobarbital is almost completely metabolized in animals and man. The major metabolite is 3'-hydroxyamobarbital. The second major metabolite in dog, mice, hamsters, guinea pigs, and rats could be identified as 3',4'-dihydroxyamobarbital. A striking contrast between man and animals is the virtual absence of the diol in man and absence of amobarbital-N-glucoside in animals.