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Zymogen granules of pancreas decrease in size in response to feeding

T H Ermak, S S Rothman

    Cell and Tissue Research
    |January 1, 1981
    PubMed
    Summary
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    Pancreatic enzyme secretion involves zymogen granules in acinar cells. After feeding, these granules decrease in size and number, supporting the equilibrium hypothesis for digestive enzyme release.

    Area of Science:

    • Cell Biology
    • Gastroenterology
    • Physiology

    Background:

    • Zymogen granules store pancreatic digestive enzymes.
    • Early observations noted granule changes after feeding.

    Purpose of the Study:

    • Quantify changes in pancreatic zymogen granule size and number after feeding.
    • Investigate the mechanism of digestive enzyme secretion.

    Main Methods:

    • Quantitative electron microscopy was used.
    • Rats were fasted then fed, with granule analysis 90 minutes post-feeding.

    Main Results:

    • Granule number decreased from 45 to 29 per cell section.
    • Mean granule diameter reduced, resulting in a 55% decrease in average volume.

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  • Observed size reduction alone or with number reduction, but not number reduction alone.

    • Conclusions:

    • Feeding reduces pancreatic zymogen granule size and number.
    • Results support the equilibrium hypothesis for enzyme secretion, suggesting protein loss across granule membranes.