Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum IgM in primary biliary cirrhosis

B G Taal, S W Schalm, A M de Bruyn

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |December 22, 1980
    PubMed
    Summary

    Serum immunoglobulin M (IgM) levels are elevated in primary biliary cirrhosis (PBC) patients, making it a sensitive screening test. Standardization of IgM measurement methods is needed for accurate clinical interpretation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    High-Statistics Measurement of Collins and Sivers Asymmetries for Transversely Polarized Deuterons.

    Physical review letters·2024
    Same author

    Final COMPASS Results on the Transverse-Spin-Dependent Azimuthal Asymmetries in the Pion-Induced Drell-Yan Process.

    Physical review letters·2024
    Same author

    Measurement of polarization observables <math></math>, <math></math>, and <math></math> in <math></math> and <math></math> photoproduction off quasi-free nucleons.

    The European physical journal. A, Hadrons and nuclei·2023
    Same author

    Performance of commercial SARS-CoV-2 wild-type and Omicron BA.1 antibody assays compared with pseudovirus neutralization tests.

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2023
    Same author

    Correspondence.

    Buffalo medical journal·2023
    Same author

    Development and validation of the German translation of the views on inpatient care (VOICE-DE) outcome measure to assess service users' perceptions of inpatient psychiatric care.

    Journal of mental health (Abingdon, England)·2022

    Area of Science:

    • Immunology
    • Hepatology
    • Clinical Chemistry

    Background:

    • Primary biliary cirrhosis (PBC) is a chronic liver disease characterized by autoimmune destruction of bile ducts.
    • Elevated serum immunoglobulin M (IgM) is a hallmark of PBC, but its measurement requires standardization.

    Purpose of the Study:

    • To compare serum IgM levels in PBC patients and controls using two different measurement techniques.
    • To assess the utility of serum IgM as a screening test for cholestasis.
    • To investigate potential differences in IgM structure or presence in PBC patients.

    Main Methods:

    • Serum IgM concentrations were measured in 25 PBC patients and 25 controls using the classical Mancini technique and a modified method involving reduction to 7 S monomers.
    • Standards were calibrated against the WHO standard and a serum standard with an absolute IgM value.

    Main Results:

    • All PBC patients exhibited elevated serum IgM levels, suggesting its utility as a sensitive screening test for cholestasis.
    • Average IgM levels varied significantly depending on the calibration standard used, highlighting the need for further standardization.
    • Discrepancies between pentameric and monomeric IgM measurements suggest possible unique IgM subgroups or in vivo monomeric IgM in PBC patients.

    Conclusions:

    • Serum IgM measurement is a simple and sensitive screening test for cholestasis, particularly in PBC.
    • Significant variations in IgM quantification underscore the critical need for improved standardization of immunoassay methods.
    • Observed differences in IgM forms may indicate distinct IgM subclasses or the presence of monomeric IgM in vivo within the PBC cohort.

    Related Experiment Videos