Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Meperidine binding in maternal and fetal plasma

R L Nation

    Clinical Pharmacology and Therapeutics
    |April 1, 1981
    PubMed
    Summary

    Maternal plasma shows higher meperidine protein binding than fetal plasma, primarily due to differences in alpha-1-acid glycoprotein and albumin levels. This explains why fetal meperidine concentrations are not due to increased protein binding.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Multiomics informed mathematical model for meropenem and tobramycin against hypermutable Pseudomonas aeruginosa.

    International journal of antimicrobial agents·2025
    Same author

    In pursuit of the triple crown: mechanism-based pharmacodynamic modelling for the optimization of three-drug combinations against KPC-producing Klebsiella pneumoniae.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
    Same author

    Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
    Same author

    Assessment and modelling of antibacterial combination regimens.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2017
    Same author

    Impact of vanB vancomycin-resistant enterococcal bacteraemia analysed as a time-varying covariate on length of hospital stay.

    Epidemiology and infection·2014
    Same author

    Enterococcal bacteraemia: factors influencing mortality, length of stay and costs of hospitalization.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2013

    Area of Science:

    • Pharmacology
    • Perinatal Medicine
    • Biochemistry

    Background:

    • Meperidine (Demerol) is a commonly used opioid analgesic during labor.
    • Understanding its protein binding in maternal and fetal plasma is crucial for assessing neonatal exposure.
    • Plasma protein concentrations, particularly alpha-1-acid glycoprotein (alpha 1-AGP) and albumin, can influence drug distribution.

    Purpose of the Study:

    • To quantify and compare meperidine protein binding in maternal and fetal plasma at delivery.
    • To investigate the role of alpha 1-AGP and albumin in meperidine binding.
    • To elucidate the relationship between protein binding and observed meperidine concentrations in mother and fetus.

    Main Methods:

    • Meperidine protein binding was measured using maternal and fetal plasma samples obtained at delivery.
    • Binding ratios (bound/free, B/F) were calculated.
    • Correlation analyses were performed between meperidine binding and plasma concentrations of alpha 1-AGP and albumin.
    • In vitro studies with purified alpha 1-AGP were conducted.

    Main Results:

    • Meperidine protein binding was significantly higher in maternal plasma (63.3%) compared to fetal plasma (51.7%).
    • Higher concentrations of alpha 1-AGP were found in maternal plasma, correlating positively with meperidine B/F.
    • Albumin concentration showed an inverse correlation with meperidine B/F in both maternal and fetal samples.
    • Alpha 1-AGP and albumin together accounted for 75% of the variability in meperidine binding.

    Conclusions:

    • Maternal plasma exhibits greater meperidine protein binding than fetal plasma.
    • Differences in maternal and fetal alpha 1-AGP concentrations contribute to the observed binding differential.
    • The higher total meperidine concentration often observed in fetal plasma is not attributable to more extensive protein binding in the fetus.

    Related Experiment Videos