Related Experiment Videos
[Pancreatic lipase: reference values at 25 degrees C (author's transl)]
Deutsche Medizinische Wochenschrift (1946)
|February 20, 1981
Summary
A new pancreatic lipase test establishes reference values, with an upper range of 190 U/l. Values above this indicate potential pathology, simplifying clinical interpretation of lipase activity.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Enzymology
Context:
- Pancreatic lipase (EC 3.1.1.3.) is crucial for fat digestion.
- Accurate estimation of pancreatic lipase activity requires established reference ranges.
- Previous methods may lack specificity or require complex standardization.
Purpose:
- To establish reference values for a new specific pancreatic lipase activity assay.
- To define normal, borderline, and pathological ranges for clinical use.
- To assess the influence of age and sex on lipase activity measurements.
Summary:
- A new assay for pancreatic lipase activity was developed and validated.
- Reference values were determined using a cohort of 368 females and 435 males (aged 20-70 years).
- An upper reference limit of 190 U/l at 25°C was established, with values below 170 U/l considered normal and above 190 U/l pathological. Intermediate values warrant further investigation.
Impact:
- Provides a reliable and specific diagnostic tool for pancreatic function assessment.
- Simplifies interpretation of lipase activity results in clinical settings.
- Facilitates earlier and more accurate diagnosis of pancreatic disorders.