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Related Experiment Videos

Dietary methionine does not reduce penetrance in curly tail mice but causes a phenotype-specific decrease in

H W van Straaten1, H Blom, M C Peeters

  • 1Department of Anatomy/Embryology, School of Medicine, University of Limburg, Maastricht, Netherlands.

The Journal of Nutrition
|November 1, 1995
PubMed
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L-methionine supplementation did not reduce neural tube defect penetrance in curly tail (CT) mice. This mouse model showed no derangement in L-methionine handling, unlike other mutants.

Area of Science:

  • Developmental biology
  • Genetics
  • Toxicology

Background:

  • The curly tail (CT) mouse mutation exhibits incomplete penetrance and variable expression of neural tube defects, specifically lumbosacral spina bifida.
  • L-methionine has previously shown efficacy in reducing neural tube defect penetrance in the Axd mouse mutant.

Purpose of the Study:

  • To investigate the potential therapeutic effects of L-methionine on the curly tail mouse model of neural tube defects.
  • To assess L-methionine handling and serum homocysteine levels in curly tail mice.

Main Methods:

  • Acute and chronic administration of L-methionine to pregnant curly tail mice.
  • Embryo weight assessment at day 13 of gestation.
  • L-methionine loading tests and serum homocysteine assays in various mouse strains, including CT and straight tail (ST) littermates.

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Main Results:

  • Neither acute nor chronic L-methionine administration reduced the penetrance of the curly tail phenotype.
  • Chronic L-methionine supplementation unexpectedly decreased embryo weight in straight tail (ST) but not curly tail (CT) dams.
  • Curly tail (CT) and straight tail (ST) mice exhibited intermediate basal and post-loading serum homocysteine levels, similar to each other and within the range of other tested strains.

Conclusions:

  • L-methionine does not appear to be a beneficial agent for reducing neural tube defect penetrance in the curly tail mouse model.
  • The curly tail mouse strain does not display abnormalities in L-methionine metabolism or handling relevant to this phenotype.