Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SA gene and hypertension

N J Samani1, D Lodwick

  • 1Department of Cardiology, Glenfield Hospital, Leicester, UK.

Journal of Human Hypertension
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

The SA gene shows higher kidney expression in spontaneously hypertensive rats (SHR), suggesting a novel blood pressure regulation system. This gene

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank.

Nature aging·2023
Same author

SVEP1 influences monocyte to macrophage differentiation via integrin α4β1/α9β1 and Rho/Rac signalling.

Biochimica et biophysica acta. Molecular cell research·2023
Same author

Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects.

Molecular psychiatry·2022
Same author

Tumour biomarkers: association with heart failure outcomes.

Journal of internal medicine·2020
Same author

Novel endotypes in heart failure: effects on guideline-directed medical therapy.

European heart journal·2018
Same author

Response to the letter by Esteves et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2018
Same journal

Patient out-of-pocket costs for antihypertensive single pill combination products with cost caps.

Journal of human hypertension·2026
Same journal

Mindfulness based interventions for blood pressure reduction: systematic and umbrella review of existing meta-analyses.

Journal of human hypertension·2026
Same journal

Invasive observation of reactive systolic blood pressure responses to upper-arm cuff inflation.

Journal of human hypertension·2026
Same journal

Association between post-thrombectomy blood pressure trajectories and clinical outcomes in hypertensive patients with acute ischemic stroke: a retrospective cohort study.

Journal of human hypertension·2026
Same journal

Systemic inflammation indices generated from first-trimester blood tests can be potential biomarkers for predicting preeclampsia.

Journal of human hypertension·2026
Same journal

Chronotherapy in hypertension: a systematic review and meta-analysis of antihypertensive dosing timing on cardiovascular outcomes.

Journal of human hypertension·2026
See all related articles

Area of Science:

  • Nephrology
  • Genetics
  • Cardiovascular Research

Background:

  • The SA gene was identified due to its elevated expression in the kidneys of spontaneously hypertensive rats (SHR) compared to normotensive Wistar-Kyoto rats.
  • Studies show the SA gene allele from SHR and other hypertensive strains cosegregates with increased blood pressure in F2 progeny.

Purpose of the Study:

  • To investigate the role of the SA gene in the development of hypertension.
  • To explore the potential of SA as a novel blood pressure regulatory system.

Main Methods:

  • Differential hybridization was used to identify the SA gene.
  • Genetic crosses and analysis of F2 progeny were performed to study gene-disease association.
  • In situ localization studies identified the gene's presence in the proximal tubule.

Related Experiment Videos

Main Results:

  • SA gene expression is significantly higher in the SHR kidney.
  • This increased expression occurs early in development, preceding the rise in blood pressure.
  • The elevated expression is genotype-dependent and localized to the proximal tubule.

Conclusions:

  • The SA gene is a potential key player in a novel blood pressure regulation system.
  • It may represent a primary renal mechanism predisposing individuals to hypertension.