Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone growth in thalassaemic children

P Lapatsanis, A Divoli, H Georgaki

    Archives of Disease in Childhood
    |December 1, 1978
    PubMed
    Summary

    Children with thalassemia showed normal bone length growth until age 11, after which it decreased. Bone width growth was initially faster in these children, and bone age retardation was more common after age 7.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The PETRRA positron camera: design, characterization and results of a physical evaluation.

    Physics in medicine and biology·2005
    Same author

    METIS: multiple extraction techniques for informative sentences.

    Bioinformatics (Oxford, England)·2005
    Same author

    Purpura fulminans complicating pneumococcal sepsis.

    European journal of pediatrics·1999
    Same author

    Diet during pregnancy and the risk of cerebral palsy.

    The British journal of nutrition·1998
    Same author

    Adolescents in high-risk trajectory: clustering of risky behavior and the origins of socioeconomic health differentials.

    Preventive medicine·1997
    Same author

    Treatment of complicated pulmonary echinococcosis with albendazole in childhood.

    Scandinavian journal of infectious diseases·1997

    Area of Science:

    • Pediatric Endocrinology
    • Orthopedics
    • Hematology

    Background:

    • Thalassemia is a genetic blood disorder affecting hemoglobin production.
    • Bone abnormalities are a known complication in children with thalassemia.
    • Understanding skeletal growth patterns is crucial for managing thalassemia complications.

    Purpose of the Study:

    • To investigate the impact of thalassemia on metacarpal bone growth in children.
    • To compare bone length and width dimensions between thalassemic and control groups.
    • To assess the correlation between thalassemia and bone age retardation.

    Main Methods:

    • X-ray measurements of the 3 middle metacarpal bones (length and width) were performed.
    • A cohort of 61 children with thalassemia and 35 healthy controls (aged 5-13 years) was studied.
    • Bone age was assessed in both groups.

    Main Results:

    • Thalassemic children exhibited normal bone length growth until age 11, followed by reduced growth.
    • Bone width growth in thalassemic children exceeded controls until age 11, then became comparable.
    • A higher proportion of thalassemic children showed bone age retardation after 7 years of age.

    Conclusions:

    • Thalassemia significantly affects metacarpal bone growth, particularly after age 11.
    • Altered bone width and length patterns are observed in children with thalassemia.
    • Bone age retardation is a more frequent finding in thalassemic children over 7 years old.

    Related Experiment Videos